Florida scientists partner to create new brain-penetrant bicyclic peptides to protect against opioid overdose

In an article published in the journal Molecules, a team of scientists from Florida Atlantic University and the University of Florida reported a novel chemical approach to deliver peptide medications directly to the brain via the olfactory nerve. Connecting the potent mu-opioid receptor antagonist CTOP to the carrier odorranalectin, the team characterized the rapid passage of this bicyclic peptide, OL-CTOP, into the brain. They then showed that intranasal administration of OL-CTOP protected against the respiratory depression induced by morphine, demonstrating it might be a new treatment for opioid overdose.

The study was led by Jay McLaughlin, Ph.D., a professor of pharmacodynamics in the UF College of Pharmacy.

To read the study, visit: https://www.mdpi.com/1420-3049/28/4/1822#B73-molecules-28-01822