Maddalena Parafati, Ph.D.
Research Assistant Professor
Teaching Profile
Courses Taught
2024
PHA5561 Pathphys-Pt Assess II
Research Profile
Open Researcher and Contributor ID (ORCID)
0000-0002-7627-2729
Areas of Interest
- Biochemistry and Cell Biology
Publications
2023
Autophagy and neuroprotection in astrocytes exposed to 6-hydroxydopamine is negatively regulated by NQO2: relevance to Parkinson’s disease.
Scientific reports.
13(1)
[DOI] 10.1038/s41598-023-44666-7.
[PMID] 38062122.
2023
Human skeletal muscle tissue chip autonomous payload reveals changes in fiber type and metabolic gene expression due to spaceflight.
NPJ microgravity.
9(1)
[DOI] 10.1038/s41526-023-00322-y.
[PMID] 37714852.
2023
Validation of Human Skeletal Muscle Tissue Chip Autonomous Platform to Model Age-Related Muscle Wasting in Microgravity.
Research square.
[DOI] 10.21203/rs.3.rs-2631490/v1.
[PMID] 37034730.
2022
Microphysiological system for studying contractile differences in young, active, and old, sedentary adult derived skeletal muscle cells
Aging Cell.
21(7)
[DOI] 10.1111/acel.13650.
[PMID] 35653714.
2021
Apigenin and Luteolin Regulate Autophagy by Targeting NRH-Quinone Oxidoreductase 2 in Liver Cells
Antioxidant.
10(5)
[DOI] 10.3390/antiox10050776.
[PMID] 34068281.
2020
Pluripotent Stem Cell-Derived Hepatocytes Phenotypic Screening Reveals Small Molecules Targeting the CDK2/4-C/EBPα/DGAT2 Pathway Preventing ER-Stress Induced Lipid Accumulation
International Journal of Molecular Sciences.
21(24)
[DOI] 10.3390/ijms21249557.
[PMID] 33334026.
2019
Atherogenic Index Reduction and Weight Loss in Metabolic Syndrome Patients Treated with A Novel Pectin-Enriched Formulation of Bergamot Polyphenols
Nutrients.
11(6)
[DOI] 10.3390/nu11061271.
[PMID] 31167512.
2019
Oxidative Imbalance and Kidney Damage in Cafeteria Diet-Induced Rat Model of Metabolic Syndrome: Effect of Bergamot Polyphenolic Fraction.
Antioxidants (Basel, Switzerland).
8(3)
[DOI] 10.3390/antiox8030066.
[PMID] 30884780.
2018
A nonalcoholic fatty liver disease model in human induced pluripotent stem cell-derived hepatocytes, created by endoplasmic reticulum stress-induced steatosis.
Disease models & mechanisms.
11(9)
[DOI] 10.1242/dmm.033530.
[PMID] 30254132.
2018
Analysis of proautophagic activities of Citrus flavonoids in liver cells reveals the superiority of a natural polyphenol mixture over pure flavones.
The Journal of nutritional biochemistry.
58:119-130
[DOI] 10.1016/j.jnutbio.2018.04.005.
[PMID] 29890411.
2018
Bergamot Polyphenols Boost Therapeutic Effects of the Diet on Non-Alcoholic Steatohepatitis (NASH) Induced by “Junk Food”: Evidence for Anti-Inflammatory Activity.
Nutrients.
10(11)
[DOI] 10.3390/nu10111604.
[PMID] 30388763.
2018
Dibutyryl cAMP- or Interleukin-6-induced astrocytic differentiation enhances mannose binding lectin (MBL)-associated serine protease (MASP)-1/3 expression in C6 glioma cells
Archives of Biochemistry and Biophysics.
653:39-49
[DOI] 10.1016/j.abb.2018.06.016.
2015
Bergamot polyphenol fraction prevents nonalcoholic fatty liver disease via stimulation of lipophagy in cafeteria diet-induced rat model of metabolic syndrome.
The Journal of nutritional biochemistry.
26(9):938-48
[DOI] 10.1016/j.jnutbio.2015.03.008.
[PMID] 26025327.
2015
Parkinsonian toxin-induced oxidative stress inhibits basal autophagy in astrocytes via NQO2/quinone oxidoreductase 2: Implications for neuroprotection.
Autophagy.
11(7):1063-80
[DOI] 10.1080/15548627.2015.1058683.
[PMID] 26046590.
2013
The antidote effect of quinone oxidoreductase 2 inhibitor against paraquat-induced toxicity in vitro and in vivo.
British journal of pharmacology.
168(1):46-59
[DOI] 10.1111/j.1476-5381.2012.01870.x.
[PMID] 22289031.
2009
Conformational and biochemical characterization of a biologically active rat recombinant Protease Nexin-1 expressed in E. coli.
Biochimica et biophysica acta.
1794(4):602-14
[DOI] 10.1016/j.bbapap.2008.12.006.
[PMID] 19167525.
2009
Localization of tyrosine hydroxylase immunoreactive neurons in the forebrain of the guppyPoecilia reticulata
Journal of Fish Biology.
75(6):1194-1205
[DOI] 10.1111/j.1095-8649.2009.02339.x.
Grants
Jul 2015
ACTIVE
UF component for SRI program
Role: Project Manager
Funding: UNIV OF CENTRAL FLORIDA SPACE INST
via FL LEGISLATURE
Contact Details
Phones:
- Business:
- (352) 294-8940
Emails:
- Business:
- mparafati@ufl.edu
Addresses:
- Business Mailing:
-
1345 Center Drive, p1-31
College of Pharmacy, Department of Pharmacodynamics
Gainesville FL 32610 - Business Street:
-
1345 Center Drive, p1-31
College of Pharmacy, Department of Pharmacodynamics
Gainesville FL 32610