Satyamaheshwar Peddibhotla, Ph.D.

As a Research Assistant Professor in the college of Pharmacy, University of Florida, I have over 15 years of experience in synthetic/medicinal chemistry, devoted to SAR-based discovery and optimization of small molecules leads, synthesis of active pharmaceutical intermediates and proteomic probes across multiple therapeutic areas including cancer, addiction, metabolic diseases and infectious diseases. As a Senior Scientist at Sanford Burnham Prebys Medical Discovery Institute, I have led hit to lead optimization and scale up chemistry to support in vitro and in vivo studies for both phenotypic and specific target driven projects. This work contributed to 12 probes for the NIH Molecular Libraries Program (MLPCN). I have led programs to translate 4 of these probes/hits to in vivo leads under the Florida Translational Research Program (FTRP). In addition, my doctoral work focused on discovering metal-catalyzed cycloadditions aimed towards Diversity Oriented Synthesis (DOS) of heterocyclic libraries that are rich in stereochemical diversity and access novel chemical and biological space. I have also led efforts to develop a “chemical toolbox” for a direct access to natural product proteomic probes to derive SAR information and allow rapid identification of the biological targets in my post-doctoral research. This has provided me the requisite experience in data driven design of analogs, chemo- and site-selective reagent development, stereoselective synthesis, and efficient construction of heterocyclic scaffolds including metal catalyzed processes, parallel synthesis, purification, and characterization to deliver the intended molecules.

As a Research Assistant Professor in the college of Pharmacy, University of Florida, I manage the Hit-to-Lead and Lead Optimization programs for development of preclinical leads in Malany research group in the Pharmacodynamics department. I have over 15 years of experience in synthetic/medicinal chemistry, devoted to SAR-based discovery and optimization of small molecules leads, synthesis of active pharmaceutical intermediates and proteomic probes across multiple therapeutic areas including cancer, addiction, metabolic diseases and infectious diseases. As a Senior Scientist at Sanford Burnham Prebys Medical Discovery Institute, I have led hit to lead optimization and scale up chemistry to support in vitro and in vivo studies for both phenotypic and specific target driven projects. This work contributed to 12 probes for the NIH Molecular Libraries Program (MLPCN). I have led programs to translate screening probes/hits to in vivo preclinical leads under the Florida Translational Research Program (FTRP). In addition, my doctoral work focused on discovering metal-catalyzed cycloadditions aimed towards Diversity Oriented Synthesis (DOS) of heterocyclic libraries that are rich in stereochemical diversity and access novel chemical and biological space. I have also led efforts to develop a “chemical toolbox” for a direct access to natural product proteomic probes to derive SAR information and allow rapid identification of the biological targets in my post-doctoral research. This has provided me the requisite experience in data driven design of analogs, chemo- and site-selective reagent development, stereoselective synthesis, and efficient construction of heterocyclic scaffolds including metal catalyzed processes, parallel synthesis, purification, and characterization to deliver the intended molecules. I am experienced in critical review of biological and ADME data in order to direct project outcomes along with the biology & pharmacology teams. I am experienced in managing a pool of remotely located chemists (CRO) assigned for rapid analog synthesis and liaise with outsourcing point of contact in the team to ensure optimum transfer of the enabled chemistry. I have interacted with cross-functional teams and assisted the discovery team in identifying and validating new targets, including collaborative engagement with the internal and external scientific community for grant preparation, selection and/or synthesis of small molecule probes/leads. I have prepared quotes and provided fee-for-service synthesis of small molecule tools, standards and APIs for biomedical investigations by internal/external clients.I have authored several publications and patent applications. In addition, I am well-versed in communication and effective participation in multidisciplinary teams and its importance in driving project outcomes.

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• Chemical biology
• Chemoresistance Pathways in Cancer
• Development of Allosteric Modulators of Particulate Guanylate Cyclase for Treatment of Hypertension and Heart Failure
• Development of Chemokine Receptor Antagonists for Treatment of Liver Cancer
• Medicinal chemistry
• Small molecule drug discovery